Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis (Mtb), which causes tuberculosis featuring lung ...

Gasdermins comprise a family of pore-forming proteins that execute lytic forms of programmed cell death, most notably pyroptosis. Under homeostatic conditions, gasdermin N-terminal domains are held ...

Researchers have identified a previously overlooked mechanism of brain cell death that appears to play a major role in ...

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central regulators of programmed cell death pathways, undergo precise modulation ...

AbstractNon apoptotic cell death programs particularly ferroptosis and cuproptosis are transforming how we understand cancer ...

The team worked for 10 years to uncover the hidden brain-cell death process fueling several dementias, revealing a key new ...

Markers of a new mechanism for cell death, called karyoptosis, have been found in the brains of patients with Alzheimer's disease and frontotemporal dementia (FTD). Subscribe to our newsletter for the ...

This image summarizes the main findings of the study, showing the multifaceted effects that exposure to 25-hydroxycholesterol (25-OHC) has on Schwann cells. Oxysterols are a class of molecules derived ...

Autophagy, the cell’s essential 'housekeeping' process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all life ...

As we age, our ability to maintain healthy blood and a strong immune system gradually declines, largely because hematopoietic stem cells (HSCs), the cells responsible for producing all blood cell ...

Published in the open-access journal Ferroptosis and Oxidative Stress, the review by Giovanni Cravin and Giorgio Cozza from ...