Loss of Dnmt1 disrupted normal DNA methylation in chondrocytes, leading to increased expression of genes involved in cellular energy metabolism. As a result, metabolic abnormalities occurred, ...

Published in Engineering, the study confirms that the dual-drug-loaded hydrogel promotes cartilage repair through synergistic immune regulation and chondrocyte differentiation, offering a novel ...

A research team from Northwest University, China, has developed a breakthrough nano-composite hydrogel system to address the dual challenges of inflammation and cartilage damage in osteoarthritis (OA) ...

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect ...