DNA helicases are ATP-dependent motor proteins that unwind duplex DNA and remodel nucleic acid structures, underpinning virtually all facets of genome maintenance. In response to DNA lesions such as ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 Reviewed For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

Regulated helicase activation by DDK kinase is central for genome stability. However, how DDK phosphorylation primes the MCM2-7 double hexamer (DH) for Sld3-Sld7 binding and Cdc45 loading remained ...

A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...

A research team led by Dr. Yuanliang Zhai from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology ...

Structural view of the MCM2-7 helicase with Sld3, Sld7 and Cdc45 bound at the site where Cdc45 is delivered. Structure derived from cryogenic electron microscopy data. Noguchi et al., 2026.