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Ubiquitin ligases are pivotal in safeguarding genome integrity by covalently attaching ubiquitin to proteins involved in the detection, signalling and resolution of DNA lesions. Among these, ...

Most of the new generation of DNA sequencing machines rely on two reactions to prepare DNA for use: DNA ligation, and the Polymerase Chain Reaction. In this post, we'll explain how these are used to ...

Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to reach the areas where they form neural circuits in the brain cortex. In a ...

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision. In the ...