The Fanconi anaemia pathway is a multi-component DNA damage response system devoted to the recognition and repair of DNA interstrand crosslinks (ICLs) that impede replication and transcription.

A new study in fruit flies describes how an animal's gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

The class of drugs known as DNA Damage Response inhibitors, which work by blocking cancer cells’ ability to repair their own damaged DNA, is expanding rapidly beyond its original anchor, the PARP ...

A repurposed small molecule originally developed for spinal cord injury has demonstrated the ability to address multiple ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

DNA polymerases are central to the faithful duplication and maintenance of the genome. Beyond replication, specialised polymerases are recruited to distinct repair pathways to restore integrity after ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

"The DNA inside our cells is constantly experiencing damage, and DNA repair is happening all the time to fix that damage and keep our cells healthy. Now, however, it seems these repair processes can ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Squamous cell carcinoma (SCC) is one of the most common cancers worldwide. It can develop in the skin (cutaneous SCC) or in the head and neck region. While skin SCC rarely spreads, it can be ...

Many cancer-associated mutational signatures remain unexplained. Team CAUSE aims to connect DNA damage, mutational patterns, ...