Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

DNA replication proceeds through specialised structures known as replication forks, where parental duplex DNA is unwound and copied. The faithful progression and stability of these forks are essential ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

Reversed DNA replication forks protect against stress to maintain genomic stability and serve as central components to cancer resistance, disease suppression, aging and immunotherapy response ...

New research shows that triple-negative breast cancer cells rely on shared DNA damage tolerance enzymes such as POLζ and CHK1 ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF.

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...