A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and the middle. Is everything packed? What time should we leave? Will there be ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...