In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing. Here we show that the N-terminal intrinsically ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

DNA replication is the process by which a cell makes an identical copy of its DNA. This process is performed at the beginning of every cell division so that when the cell divides, each daughter cell ...

Segmental copy-number gains are major contributors to human genetic variation and disease, but how these alterations arise remains incompletely understood. Here, based on the analyses of both ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

So-called junk DNA was given that unfortunate nickname because its function was so mysterious. These vast regions of the genome do not code for protein and are made up of highly repetitive sequences.

The Polymerase Chain Reaction (PCR) is a technique for the amplification of DNA in vitro (this describes experiments with cells outside their normal environment). PCR amplifies DNA using complementary ...