A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer ...

The initiation of DNA replication in eukaryotic cells begins with the assembly of pre-replicative complexes (pre-RCs) at many sites along each chromosome during the G1 phase of the cell cycle. Pre-RCs ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Repetitive sequences make extrachromosomal DNA vulnerable to breaks, which could be exploited for therapy — but might also promote tumour evolution.

A team led by Professor Kazuhiro Maeshima of the National Institute of Genetics (ROIS) and SOKENDAI in Japan has developed a method to visualize different types of chromatin and reveal their distinct ...

I have completed a master's degree in a science-related graduate school and work as a researcher at a manufacturing company.

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...