The molecular mechanisms that underpin the multi-organ dysfunction in long COVID are unknown, particularly within the cardiovascular system. Research finds a critical role for endothelial responses ...

Microvascular endothelial dysfunction is an early or inductive event that occurs in the development of cardiovascular diseases and associated organ damage. The endothelium is composed of a single ...

Smoking is associated with vascular endothelial dysfunction. It is thought that smoking impairs vascular endothelial function through a decrease in nitric oxide bioavailability induced by activation ...

The glycocalyx emerges as an active endothelial system whose structure, metabolism, and shear-dependent regulation integrate mechanical forces with vascular signaling. Disruption of this system ...

Sepsis, a life-threatening systemic inflammatory response triggered by infection, has long challenged clinicians with its persistently high mortality (up to 40-50% in septic shock). At the heart of ...