A new review in the Journal of Molecular Medicine explains how trained immunity, driven by epigenetic and metabolic ...

SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may ...

December 4, 2024 – Jérémie Le Pen wants to understand the workings of the “innate immune system”—the part of the human immune system that puts up an immediate defense when it encounters a pathogen.

He began searching for novel parasite-fighting immune cells. McKenzie knew that IL-25 triggers a class of T cells called type-2 helper T cells (Th2s) to proliferate and produce IL-13, and he wondered ...

Scientists generally agree that eukaryotes, the domain of life whose cells contain nuclei and that includes almost all multicellular organisms, originated from a process involving the symbiotic union ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential ...

We sometimes hear about the benefits of “boosting” our immune system, but what we really want to do is support our immune system on an ongoing basis. People often think of the immune system as ...

A new review in the Journal of Translational Medicine proposes that the physical mechanics of solid tumors govern whether ...

Jérémie Le Pen, assistant professor of immunology and infectious diseases at Harvard T.H. Chan School of Public Health, shares one thing everyone should know about the innate immune system, our body’s ...

Unlike transient innate immune activation, trained immunity is characterized by long-lasting but reversible functional reprogramming of monocytes, macrophages, natural killer (NK) cells, and ...

During the recent Covid-19 pandemic, the rate of serious illness and death was jarringly high in older populations. Why? Weakening immune systems — as we age, we become more vulnerable to infections, ...