In 1978, Temtamy and McKusick classified isolated, non-syndromic Polydactyly and syndactyly, using a logical anatomical approach, into five distinct types for each group. Since then, there have been ...

Three-dimensional image of a developing limb bud generated using LimbLab. It shows where key genes are active during early limb formation. Sox9 (magenta) marks the cells that will become cartilage and ...

Limb malformations represent a diverse group of congenital anomalies that vary in clinical presentation, severity and underlying aetiology. Advances in genetic research have increasingly implicated ...

This study is reported by Jia-Tang Li’s group from the Chengdu Institute of Biology, Chinese Academy of Sciences. The development of limbs is significant for the origin and evolution of tetrapods, ...

Scientists at EPFL have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue ...

Globally, close to 60 million people are living with limb loss. Amputations can result from various medical conditions such as tumors, infections, and birth defects, or due to trauma from industrial ...