A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

(A) FPs emit light via chromophore structural transformations and energy transitions. The chromophore forms through autocatalytic cyclization, dehydration, and oxidation of internal amino acids. Upon ...

In eukaryotic cells—found in animals, plants, and fungi—protein synthesis involves more than the simple assembly of amino acids in ribosomes. Nearly one-third of all human proteins must be transported ...