At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

PDS5B (Precocious Dissociation of Sisters 5B) functions in sister chromatid cohesion and genome organization. Interestingly, PDS5B also associates with RAD51, the recombinase required for DNA damage ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication and repair are well established, while its cytosolic roles are less explored. Two metabolic ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Structural view of the MCM2-7 helicase with Sld3, Sld7 and Cdc45 bound at the site where Cdc45 is delivered. Structure derived from cryogenic electron microscopy data. Noguchi et al., 2026.

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 ...