The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an ...

Newborn mice neurons can snap both DNA strands to migrate, then repair the breaks within a day. The process may be a normal part of brain development.

Many cancer-associated mutational signatures remain unexplained. Team CAUSE aims to connect DNA damage, mutational patterns, ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

A new study from researchers at The University of Texas MD Anderson Cancer Center has uncovered how one of the most common ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Prognosis and survival evaluation in treating high-risk BRAF V600 mutation stage III or IV melanoma with dabrafenib plus trametinib therapy: A meta-analysis of 2,660 patients.

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...