Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.

Orphan nuclear receptors influence the onset and progression of MASLD, particularly in lipid metabolism, inflammation, autophagy, and cholesterol metabolism. These receptors may play either similar or ...

Chinese Medical Journals Publishing House Co., Ltd. Brain cancer is one of the most aggressive and life-threatening diseases, with glioblastoma (GBM) being the most common and deadliest type. Patients ...

Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

A new Salk Institute study suggests estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue. Across the body, tiny bean-shaped structures called mitochondria turn ...