The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in ...
Their functions include identifying proteins that have not folded properly or in which the structure has come apart, and sending them to be refolded with the help of other chaperones. Among their ...
Schematic illustrating the effects of p53C and M237I in driving the conversion of p63C and p73C droplets into amyloid aggregates at physiologically relevant temperatures. Heparin prevents the ...
Design of a phase 1 trial of Listeria monocytogenes 11-T856-1313 tetanus toxoid (Lm-LLO-TT) for pancreatic ductal adenocarcinoma (PDAC). This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...
Outcomes of Radium-223 and Stereotactic Ablative Radiotherapy Versus Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancers: The RAVENS Phase II Randomized Trial We analyzed a cohort ...
India, May 28 -- AI-Designed p53 Proteins may help improve future cancer treatment, but the research is still at an early and experimental stage. Researchers recently proposed that artificial ...
Memorial Sloan Kettering Cancer Center investigators and collaborators have tested rezatapopt, an oral p53 reactivator designed for tumors with TP53 Y220C, and observed antitumor activity across ...
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