Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease due to a genetic defect, where your red blood cells (RBCs) do not have a protective layer of proteins. These missing proteins cause ...

Paroxysmal nocturnal hemoglobinuria leaves red blood cells more vulnerable to destruction. A common side effect is blood clots, known as thrombosis. This is largely preventable with medication to ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease. It’s also very complex. If you or a loved one has recently been diagnosed with PNH, you may wonder what sort of challenges you will ...

Autoimmune hemolytic anemia (AIHA) and paroxysmal nocturnal hemoglobinuria (PNH) are distinct blood disorders with different underlying causes and treatment approaches. Each is rare and potentially ...

Persistent hemolytic anemia and a lack of oral treatments are challenges for patients with paroxysmal nocturnal hemoglobinuria who have received anti-C5 therapy or have not received complement ...

A acquired deficiency in the PIGA gene alters red blood cells. Paroxysmal nocturnal hemoglobinuria results when these altered cells replicate. Medications can stop the breakdown of red blood cells and ...

Iptacopan demonstrated significant hemoglobin improvements in PNH patients transitioning from anti-C5 therapies, validating its efficacy as an oral monotherapy. The safety profile of iptacopan was ...

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, potentially life-threatening disorder linked to a specific gene. It can occur at any age but most often is diagnosed in young adults. PNH ...

Machine learning models can identify undiagnosed PNH cases by analyzing EHR data, potentially transforming rare disease diagnostics. PNH symptoms overlap with other conditions, leading to frequent ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease that develops when your blood cells are formed. It can lead to the abnormal destruction of blood cells, resulting in various symptoms.