Identifying conditions that maximize the structural stability of a biologic’s native state is essential for developing therapeutics, formulations, and process development conditions. In this GEN ...

Bioprocessors must minimize the aggregation of therapeutic proteins, but that’s not an easy task. Proteins can aggregate during any step from manufacturing to administering a drug. “The aggregation ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical ...

The COVID-19 pandemic brought about by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) led to the disruption of the global economy and the loss of human lives. Studies are still ...

Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Researchers propose the concept of a 'protein aggregation clock' to measure aging and ...

Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link ...