Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...

Breakthrough Designation: Pivotal Trials Lack Randomization, Double-Blinding and Control Groups A review of all therapeutics receiving a breakthrough designation and approved from 2012 to 2017 found a ...

In a randomized clinical trial, instead of allocating patients equally between the treatment arms, some trials in oncology assign a higher proportion of patients to receive the experimental treatment ...

Questions remain concerning the rapidity of immune responses and the durability and safety of vaccines used to prevent Zaire Ebola virus disease. We conducted two randomized, placebo-controlled trials ...