Cysteine-Rich Secretory Proteins (CRISPs) constitute a conserved family of small, secreted proteins characterised by an N-terminal PR-1 domain and a distinctive cysteine-rich C-terminal region.

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease. A recent research collaboration between multiple Japanese ...

Avenue Biosciences received $5.7 million in seed extension to scale a high-throughput protein engineering technology designed to accelerate the discovery of protein-based tools and therapies. Balnord ...

Osaka, Japan – Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that ...

The secretory pathway in eukaryotic cells is crucial for maintaining cellular function and physiological activities, as it ensures the accurate transport of proteins to specific subcellular locations ...

Janelia researchers have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, highlighting how interactions ...

A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome ...

Randomized pilot trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancer: preliminary ...

A multicenter clinical study in Austria has shown that a new, highly precise ultrasound approach can successfully target and treat early prostate cancer while preserving patients' quality of life.

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

A unique method to screen large-scale libraries for industrially useful bacterial strains was recently developed by Tokyo Tech researchers. The simple approach combines biosensors and microfluidics to ...