The human genome comprises both canonical protein-coding genes and a vast number of non-canonical coding regions, yet the translation products of the latter remain largely underexplored. Now, the ...

Researchers have unveiled LoL-align, a probabilistic protein structure alignment algorithm that outperforms TM-align and Dali ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron ...

A new LMU study shows how proteins function reliably even without a stable 3D structure—and the crucial importance not only of short sequence motifs, but also of chemical characteristics. Many ...

Internal benchmarks show that Ptarmigan-1 can run 5,000x faster than structure-based methods and screen over three billion compounds in a day.

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing ...

This Brush Up is sponsored by Quanterix. Learn more about tau biomarkers and clinical applications. Tau is a flexible protein that stabilizes the internal structure of neurons and supports ...

A new study shows that the extraction method fundamentally reshapes the structure, flavor, functionality, and storage ...

A grayscale ribbon representation of a protein with space filling representations of a steroid (orange) and β-lactamase active site (green). One of the hormone-binding protein switches Credit: Kirill ...

As we age, the composition and function of proteins in the brain change, affecting how well our brain performs later in life—influencing memory, responsiveness, and the risk of neurodegenerative ...