Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, Krakow 30-387, Poland Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University in Krakow, ...

Aging is a major risk factor for neurodegenerative diseases, but the molecular mechanisms behind this relationship are not clear. In a recent study, researchers explored the role of PQBP3, a protein ...

Researchers investigated the function of PQBP3, a protein that was previously linked to certain neurodegenerative diseases, and unveiled its role in maintaining the integrity of the nuclear membrane.

In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured ...

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Biogenesis intermediates of nucleolar ribosomal 60S precursor particles undergo a number of structural maturation steps before they transit to the nucleoplasm and are finally exported into the ...

The size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is maintained during cell growth in many cell types. The mechanism responsible for this ...

The condensation and compartmentalization of biomacromolecules in the cell are driven by the process of phase separation. The main effectors of phase separation are intrinsically disordered proteins, ...

Mechanomemory is a response to force long after force cessation. Nuclear mechanomemory has been largely unknown. This research shows that nuclear mechanomemory is regulated by nuclear pore complexes ...