Litter boxes should be cleaned at least every 1-2 days as the average rabbit can poo at least 200-300 pellets per day, so litter boxes can get messy pretty quickly. You can clean using a pet-safe cleaning spray such as our Tiny Friends Farm Keep it Clean, or a solution of white vinegar and water. Just make sure when using any cleaning products that your rabbits are out of the room and that everything is fully dry before allowing your rabbits back in again. White vinegar can also be used to remov