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What Role Does The CYP1A2 Gene Play In Caffeine Metabolism?
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Caffeine response isn’t just “dose”—it’s liver metabolism. CYP1A2 is the key enzyme that metabolizes caffeine. When it’s slowed, caffeine remains active longer and effects intensify. • CYP1A2 converts caffeine into active metabolites (major: paraxanthine) • Genetics and inhibitors can reduce CYP1A2 activity • Caffeine may linger longer with fluvoxamine, estrogen-based contraceptives, certain antibiotics, alcohol, and grapefruit • If your caffeine effects feel inconsistent, the issue may be metab
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Caffeine response isn’t just “dose”—it’s liver metabolism. CYP1A2 is the key enzyme that metabolizes caffeine. When it’s slowed, caffeine remains active longer and effects intensify. • CYP1A2 converts caffeine into active metabolites (major: paraxanthine) • Genetics and inhibitors can reduce CYP1A2 activity • Caffeine may linger longer with fluvoxamine, estrogen-based contraceptives, certain antibiotics, alcohol, and grapefruit • If your caffeine effects feel inconsistent, the issue may be metab
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